Oligodendrocytes in the Aging Brain
نویسندگان
چکیده
منابع مشابه
Caspases determine the vulnerability of oligodendrocytes in the ischemic brain.
Although oligodendrocytes (OLGs) are thought to be vulnerable to hypoxia and ischemia, little is known about the detailed mechanism by which these insults induce OLG death. From the clinical viewpoint, it is imperative to protect OLGs as well as neurons against ischemic injury (stroke), because they are the only myelin-forming cells of the central nervous system. Using the Cre/loxP system, we h...
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Progenitors in the telencephalic subventricular zone (SVZ) remain mitotically active throughout life, and produce different cell types at embryonic, postnatal and adult stages. Here we show that Mash1, an important proneural gene in the embryonic telencephalon, is broadly expressed in the postnatal SVZ, in progenitors for both neuronal and oligodendrocyte lineages. Moreover, Mash1 is required a...
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Neurogenesis, or the birth of new neural cells, was thought to occur only in the developing nervous system and a fixed neuronal population in the adult brain was believed to be necessary to maintain the functional stability of adult brain circuitry. However, recent studies have demonstrated that neurogenesis does indeed continue into and throughout adult life in discrete regions of the central ...
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According to the United States Department of Health and Human Services Administration on Aging, more than 14 percent of the US population is 65 or older, a percentage that is predicted to steadily increase over the next several decades. The rapid growth of this segment of the population is not a phenomenon limited to the United States — the global population is aging as well. A recent report by...
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ژورنال
عنوان ژورنال: Neuronal Signaling
سال: 2021
ISSN: 2059-6553
DOI: 10.1042/ns20210008